The stability of the work of enterprises of dust-forming areas of industry critically depends on the ability of enterprises to ensure the required level of explosion and fire safety of production, which increases the relevance of improving the traditional methods used, as well as the introduction of new and additional explosion prevention measures. In the article, using mathematical and computer modeling methods, the main factors and patterns of the formation of an explosive dust situation in ventilated industrial premises with the release of combustible dust are investigated. On this basis, the possibility of using permanent general exchange ventilation to reduce the likelihood of the formation of explosive situations and prevent the occurrence of explosions and fires in dusty industrial premises is shown.