The article is devoted to the philosophical interpretation of Renaissance art as a form of cultural and existential salvation of humanity. Through the analysis of the key ideas of humanism, Neoplatonism and the aesthetics of mimesis, the transformation of artistic thinking from theocentrism to anthropocentrism is considered. Particular attention is paid to rethinking the status of the artist, the symbolic multi-layered nature of works and the conceptualization of beauty as a path to the knowledge of truth. Renaissance art is considered as a philosophical act that connects reason, spirit and harmony with visual expressiveness. The work is based on the synthesis of works by classics of the philosophy of art and modern researchers, including Scopus sources, and can be useful in the framework of art history, aesthetics, cultural history and, therefore, philosophical research.